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| Jan 8, 2006 @ 12:26 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered
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lecriveuse
Posts: 1,865
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TUESDAY, Jan. 3 (HealthDay News) -- A new study shows how and why a high-fat diet and obesity are linked to type 2 diabetes .
Researchers at the University of California, San Diego have found a molecular connection between the high-fat Western-style diet and the disruption of insulin production. A single enzyme, called GnT-4a, enables the beta cells in the pancreas to sense blood glucose levels and produce the appropriate amount of insulin.
Studies with mice show that this enzyme is suppressed by a high-fat diet, resulting in diabetes, the researchers said.
The study appears in the Dec. 29 issue of the journal Cell.
Early in the disease, diabetes patients produce insufficient insulin that results in hyperglycemia, or elevated blood glucose. Beta cells overcompensate and produce too much insulin, resulting in full-blown type 2 diabetes. More than 200 million people worldwide have been diagnosed with the disease, 20 million in the United States alone.
"In fact, the likelihood that obesity will lead to diabetes is so common that this epidemic is sometimes referred to as 'diabesity,' " Jamey Marth, a professor of cellular and molecular medicine at UCSD and an investigator with the Howard Hughes Medical Institute, said in a prepared statement.
High levels of insulin have also been implicated in contributing to other diseases such as cancer, cardiovascular disease and stroke. The researchers said new forms of treatment may include inhibiting the GnT-4a gene to reduce insulin production.
-- Meryl Harris
SOURCE: University of California
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| Jan 8, 2006 @ 12:35 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered |
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waiting41
Posts: 1,926
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This is very interesting Lecri. I have a question that I was planning to ask my doctor (he is African American). I live in a town with alot of AA people (sorry, I can't keep typing it all out  ) and have alot of AA friends (not alcoholics). Is there research showing why AA people have a much higher incidence of diabetes? Is it chemistry? Diet? I don't get it. I just always have heard this.
I always tease my friends when they talk about thier "sugar" 
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| Jan 8, 2006 @ 12:56 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered
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lecriveuse
Posts: 1,865
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heredity and lifestyle. i've included an excerpt from richard k bernstein's diabetes solution. i followed his diet for about two years, but i plunged into this huge depression; i'd crave carbs like nobody's business at night. i'd hate myself and worry about my increasing BGs cos exercise and the .75 of a pill couldn't control it. diabetes seems to affect afrikan and mexican/indian populations.
http://www.diabetes-normalsugars.com/book/chapter12.shtml
During periods of famine, those of their forebears whose bodies were not thrifty or capable of storing enough energy to survive without food died out. Those who survived were those who could survive long periods without food. How did they do it? Although it may be simplifying somewhat, the mechanism essentially works like this: Those who naturally craved carbohydrate and consumed it whenever it was available, even if they weren’t hungry, would have made more insulin and thereby stored more fat. Add to this the additional mechanism of the high insulin levels caused by inherited insulin resistance, and serum insulin levels would have become great enough to induce fat storage sufficient to enable them to live through famines. Truly survival of the fittest— provided famines would continue.
In persons with the thrifty genotype, deficiencies of these neurotransmitters (or diminished sensitivity to them in the brain) causes both a feeling of hunger and a mild dysphoria—often a sensation of anxiety, the opposite of euphoria. Eating carbohydrates temporarily causes the individual to feel not only less hungry but also more at ease. It’s the carbohydrate that will increase the level of certain neurotransmitters in her brain and make her feel better temporarily. The side effect of the carbohydrate is that it also causes her blood sugar to rise and her body to make more insulin; and, as she sits on the couch, the elevation in her serum insulin level will facilitate the storage of fat.
i know research was done on pima indians and a south afrikan tribe that bears out a traditional diet is better than a western one. i'm off to get back into working out like i did in the old days of energy.  wish me luck.  
now, i ate whatever meats i wanted on bernstein's diet, and i restricted myself to simple carbohydrates. my lipids panel was better than a non-diabetics; only when i was out of control was there a problem. i have a combo diet from ada and bernstein, and bad cholesterol et al isn't an issue. now, i dont have a lard cream cone cos that's gross. but some fats are necessary and they retard the absorption of the carbs. i use veg oil mostly; my grandmother loved lard, and her BGs weren't under control until later. she had bypass surgery and neuropathy. i must be doing something half-way right (knock on wood).
[Edited on 1/8/2006 1:07 AM]
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| Jan 8, 2006 @ 1:34 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered |
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waiting41
Posts: 1,926
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I will read this in the morning.
But good luck with the working out!! 
I really need to do it and cannot get motivated. 
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| Jan 8, 2006 @ 1:40 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered
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lecriveuse
Posts: 1,865
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lmfao. sorry, they said it better than i. basically, type IIs like me have a gene that prevented us from dying during famine. we ate carbs like nobody's business so we could survive. now, it's doing us in. big oversimplication. please read it cos it explains much clearly than i.
stop thinking! i smell ur brain burning. 
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| Jan 24 @ 6:24 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered |
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ToucherinSparks
Posts: 6,701
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Is Bernstien's diet better than Atkins' diet for carb restriction?
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| Jan 24 @ 9:36 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered
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Heaveninawildflower
Posts: 15,329
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Diabetes remission
I'd read about this yesterday - the latest take is that it's actually the weight loss and not the method of loss that matters. This only applies to type 2, type 1 sufferers are rarely overweight. For those who don't want to look at the link, the study included people with a BMI of 30-40 with diabetes 2, half were put on a diet and exercise program, half received lap band surgery (fyi, this is different from gastric bypass as it's reversible and modifiable; kind of like a rubber band around the stomach to allow stomach size to be increased if called for). 22 out of 30 with lap band, and 4 out of 30 with diet, went into remission of their diabetes.
Of course this seems to contradict what I'd read earlier, where the finding was that liposuction had no effect on diabetes. That study seemed to infer that it's the size of the fat cells, not the number (more fyi - the number of fat cells we carry is pretty much determined at birth - weight gain or loss is accomplished by expanding or deflating the fat cells we have - lipo reduces the number, but not their size).
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| Jan 24 @ 10:48 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered |
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kattsmeow
Posts: 21,270
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Is Bernstien's diet better than Atkins' diet for carb restriction?
Get a good book that tells you all the things that are carbs. Some people would be surprised at what a carb is.
Also, get a diabetic diet book, or a Weight watchers one.
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| Jan 28 @ 7:30 AM |
Molecular Link Between Diet, Type 2 Diabetes Discovered
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luvmycats
Posts: 9,740
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